Political: Claudius kills old Hamlet and usurps the throne. Denmark is also regarded as a corrupted body. This is evident by Hamlet's remark that, "something is rotten in the state of Denmark".
Incest: There are undercurrents of an incestuous relationship with his mother. Hamlet makes a number of references to her body in his first soliloquy and numerous others. His tone is entirely inappropriate at times. Hamlet expresses a great deal of disgust towards the sexual nature of his mother's relationship with Claudius. This causes his rejection of Ophelia.
Misogyny: Hamlet's relationship with his mother and disapproval of her relationship with Claudius results in his misogyny. He goes so far as to tell her, "Frailty, thy name is woman" and to tell Ophelia, "Get thee to a nunnery".
Murder (Death): Death plays a major part in the dramatic work. Death sets the events in motion (Claudius's murder of Old Hamlet) and is the final result of those events. By the end of the play, all of the major characters as well as three minor characters are dead.